David A. Sinclair
Can aging be treated by restoring lost cellular information? Lifespan frames longevity around epigenetic change, stress-response pathways, and the promise and limits of anti-aging interventions.
Aging is presented as a loss of epigenetic information that could theoretically be reversed by restoring cells to a more youthful state.
The book argues that fasting, exercise, and other controlled stressors can activate survival pathways linked to cellular repair and maintenance.
Compounds such as NMN, resveratrol, metformin, and rapamycin are discussed as ways to mimic or support these longevity pathways, though their effects are complex.