The Big Idea
Implanted deep brain stimulation can reach reward circuits such as the nucleus accumbens and modulate activity linked to severe compulsive behavior. TMS probes circuits non-invasively with different reach and precision, while focused ultrasound for psychiatric targets remains prospective. Researchers are investigating whether recordings can identify craving-related signals and guide stimulation when those signals arise, with the aim of helping patients with treatment-resistant compulsive disorders regain behavioral control.